Table 2.
- Subgroup analysis of Kupperman index between the Chinese herbal medicines group and the control group.
| Subgroups | Studies | Sample sizes | Heterogeneity test I2(%) | Effect size | ||||
|---|---|---|---|---|---|---|---|---|
| Trials | Controls | MD | 95% CI | P-values | ||||
| Monarch drug | ||||||||
| CRG | 5 | 182 | 181 | 97.7 | -15.05 | -22.94 | -7.17 | <0.01 |
| PRG | 7 | 257 | 239 | 22.21 | -9.88 | -11.34 | -8.41 | <0.01 |
| CRG+PRG | 2 | 47 | 45 | 0.00 | -13.90 | -17.18 | -10.62 | <0.01 |
| Menopausal status | ||||||||
| Postmenopausal | 5 | 160 | 155 | 72.57 | -14.34 | -17.95 | -10. 74 | <0.01 |
| Premenopausal | 4 | 128 | 128 | 91.98 | -12.28 | -17.43 | -7.13 | <0.01 |
| Both | 1 | 32 | 32 | -6.14 | -8.03 | -4.25 | <0.01 | |
| Unclear | 4 | 166 | 150 | 95.81 | -13.36 | -21.77 | -4.94 | <0.01 |
| Endocrine therapy | ||||||||
| All | 12 | 392 | 387 | 92.64 | -13.11 | -16.48 | -9.74 | <0.01 |
| Part | 2 | 94 | 78 | 85.42 | -10.91 | -17.30 | -4.51 | <0.01 |
| Treatment duration | ||||||||
| ≥3 months | 5 | 137 | 132 | 92.18 | -12.06 | -16.71 | -7.41 | <0.01 |
| <3 months | 9 | 349 | 333 | 91.61 | -13.20 | -17.23 | -9.17 | <0.01 |
PRG: processed Rehmannia glutinosa (Shudihuang), CRG: crude Rehmannia glutinosa (Shengdihuang)