Table 3.
Pharmacological Activities of bioactive compounds (main peaks selected) present in TSFME
| Peak | Compound Name of TSFME GC–MS | R.Time (Min) | Area (%) | Pharmacological Activities (Reference) |
|---|---|---|---|---|
| 1 | Cyclopentadiene, 1,2,3,4,5-pentamethyl- | 6.079 | 0.21 | NAR |
| 2 | Decane | 7.633 | 1.07 | AM [33] |
| 3 | Vanillin | 8.644 | 0.55 | AO, AIF, NRP, AC [34–36] |
| 4 | Benzeneacetic acid, 3-methoxy-α,4-bis[(trimethylsilyl)oxy]-, trimethylsilyl ester | 9.022 | 0.28 | AC, AFG, AB [65, 66] |
| 5 | Cyclopentasiloxane, decamethyl | 10.246 | 0.29 | AM [37] |
| 6 | 1,3,5,7,9-Pentamethyl Cyclopentasiloxane | 11.685 | 0.33 | NAR |
| 7 | Cyclohexasiloxane, dodecamethyl | 12.897 | 0.47 | AM [44]; AFG [45];AB, AFL, IMD and AT [47] |
| 8 | 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)−1,3-dihydro-3-hydroxy- | 14.074 | 0.36 | NAR |
| 9 | Cycloheptasiloxane, tetradecamethyl | 15.304 | 0.56 | AM [44]; AFG [45];AB, AFL, IMD and AT [46] |
| 10 | Pentasiloxane, 1,1,3,3,5,5,7,7,9,9-decamethyl- | 16.207 | 2.16 | NAR |
| 11 | 1,2-Benzenedicarboxylic acid, diethyl ester | 17.228 | 12.50 | AM, AFG, AMR [50]; AC, CT [51, 52] |
| 12 | 3,3-Dimethyl-2-phenyl-2-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl) azirane | 17.750 | 2.90 | NAR |
| 13 | n-Octacosane | 18.001 | 0.92 | AT [67], AO, WHP [68] |
| 14 | 1,1,3,3,5,5,7,7,9,9,11,11Dodecamethylhexasiloxane | 18.278 | 3.15 | AM, AST [53] |
| 15 | 2,6-Dihydroxybenzoic acid, 3TMS derivative | 18.640 | 1.04 | AM, AO, AC, CP [69] |
| 16 | 3,3-Dimethyl-2-butanone | 18.843 | 0.99 | NAR |
| 17 | Ethyl 1-hexyl-4-hydroxy-2(1H)-oxo-3 quinolinecarboxylate | 19.149 | 1.29 | NAR |
| 18 | Acetophenone, 4'-methoxy-3'-methyl- | 19.364 | 0.90 | NAR |
| 19 | Glycine, N-[[(4-methoxyphenyl)methoxy]carbonyl]-N-methyl- | 19.591 | 1.48 | NAR |
| 20 | Cyclononasiloxane, octadecamethyl | 19.876 | 1.49 | AFG [62]; AO [63, 64] |
| 21 | 3,3-Dimethyl-2-butanone | 20.259 | 1.11 | NAR |
| 22 | 2-(4,5-Dihydro-3-methyl-5-oxo-1-phenyl-4-pyrazolyl)−5-nitrobenzoic acid | 20.511 | 0.83 | AT [63] |
| 23 | Cyclododecasiloxane, tetracosamethyl | 21.039 | 2.79 | AFG [45];HP, ASP, ARH [49] |
| 24 | Norepinephrine, (R)-, 4TMS derivative | 21.878 | 0.80 | NAR |
| 25 | Cyclodecasiloxane, eicosamethyl- | 22.437 | 0.92 | AM, AHT, AO [49] |
| 26 | 9,12-Octadecadienoic acid (Z,Z)-, 2,3-bis[(trimethylsilyl)oxy]propyl ester | 22.978 | 0.42 | AF, AB, AT, AIF, HP [70–72] |
| 27 | 1H-Purin-6-amine, [(2-fluorophenyl)methyl]- | 23.359 | 0.94 | AO [60] |
| 28 | 5-Pregnene-3β,20β,21-triol TMS | 25.189 | 0.43 | NAR |
| 29 | 1,1,3,3,5,5,7,7,9,9,11,11,13,13,15,15-Hexadecamethyl-Octasiloxane | 25.463 | 1.37 | AM [55] |
AM Antimicrobial, AB Antibacterial, AT Antitumor, HP Hepatoprotective, AO Antioxidant, AC Anticancer, NAR No Activity Reported, CP Chemopreventive, AP Antiproliferative, AFG Antifungal, AFL Antifouling, AIF Anti-inflammatory, IMD Immunomodulatory, ASP Antispasmodic, ART Antirheumatic, AMR Antimalarial, CT Cytotoxicity, AHT Anthelmintic, NRP Neuroprotective, AST Antiseptic