Table 2.

Serum PK parameters of nipocalimab

	15 mg/kg (n = 10)	30 mg/kg (n = 10)b	45 mg/kg (n = 10)b
Cmax, μg/mL	337 (31)	814 (97)	1172 (115)
Tmaxa, h	0.8 (0.5–1.5)	0.5 (0.5–2.5)	0.6 (0.5–2.5)
Clast, μg/mL	2.42 (4.70)	0.02 (0.01)	0.14 (0.35)
Tlasta, h	180.6 (144.4–337.2)	263.9 (263.6–672.5)	336.1 (264.0–336.4)
AUClast, μg h/mL	17,505 (2345)	58,784 (7934)	91,738 (9344)
AUC∞, μg h/mL	17,574 (2404)	60,220 (6901)	92,963 (9023)
t1/2, h	14.3 (5.0)	9.3 (3.4)	14.1 (8.6)
Vz, L	1.1 (0.4)	0.5 (0.2)	0.7 (0.5)
CL, L/h	0.055 (0.006)	0.036 (0.005)	0.032 (0.004)

Data are mean (standard deviation) unless otherwise specified

^aData are median (range)

^bn = 9 for AUC∞, t_1/2, V_z, and CL

AUC_inf AUC from time 0 extrapolated to infinity, AUC_last area under the serum concentration–time curve from start of infusion at time 0 to the time of the last measurable concentration, CL clearance, C_last last measurable serum concentration, C_max maximum observed serum concentration, PK pharmacokinetics, t_1/2 half-life, T_last time of last measurable serum concentration, T_max time to reach the maximum observed serum concentration, V_z volume of distribution