Table 3.

Logistic regression model for predictors of original site failure

Variable	Univariate analysis			Multivariate analysis
	ORs	95% CI	P value	ORs	95% CI	P value
EGFR mutation type (L858R vs. 19del)	1.375	(0.626, 3.017)	0.428
Age (≥ 65 vs. < 65)	1.387	(0.619, 3.107)	0.427
Sex (female vs. male)	4.246	(1.802, 10.005)	0.001	3.961	(1.629, 9.631)	0.002
Smoking history (yes vs. no)	0.654	(0.236, 1.813)	0.414
Best response evaluation (PR vs. SD)	0.967	(0.399, 2.340)	0.940
Best response evaluation (PD vs. SD)	1.050	(0.341, 3.236)	0.932
Initial Oligometastatic status (yes vs. no)	1.172	(0.526, 2.613)	0.698
Initial CNS metastasis (yes vs. no)	2.851	(1.237, 6.567)	0.014	2.480	(1.024, 6.008)	0.044
Treatment line (subsequent line vs. first line)	2.077	(0.921, 4.686)	0.078	1.855	(0.766, 4.490)	0.171
Disease stage (IV vs. III)	1.015	(0.300, 3.439)	0.981

CNS, central nervous system; 95% CI, confidence interval; EGFR, epidermal growth factor receptor; ORs, odds ratios; PR, partial response; PD, progressive disease; SD, stable disease.