Table 4.

Logistic regression model for predictors of distant site failure

Variable	Univariate analysis			Multivariate analysis
	ORs	95% CI	P value	ORs	95% CI	P value
EGFR mutation type (L858R vs. 19del)	0.662	(0.268, 1.634)	0.371
Age (≥ 65 vs. < 65)	0.515	(0.193, 1.372)	0.184	0.427	(0.147, 1.238)	0.117
Sex (female vs. male)	0.379	(0.151, 0.954)	0.039	0.548	(0.157, 1.917)	0.347
Smoking history (yes vs. no)	2.404	(0.816, 7.084)	0.112	1.422	(0.315, 6.416)	0.647
Best response evaluation (PR vs. SD)	1.355	(0.477, 3.850)	0.568
Best response evaluation (PD vs. SD)	1.286	(0.347, 4.764)	0.707
Initial Oligometastatic status (yes vs. no)	1.592	(0.642, 3.947)	0.316
Initial CNS metastasis (yes vs. no)	0.186	(0.058, 0.590)	0.004	0.191	(0.058, 0.635)	0.007
Treatment line (subsequent line vs. first line)	0.427	(0.171, 1.069)	0.069	0.480	(0.176, 1.311)	0.152
Disease stage (IV vs. III)	1.667	(0.340, 8.172)	0.529

CNS, central nervous system; 95% CI, confidence interval; EGFR, epidermal growth factor receptor; ORs, odds ratios; PR, partial response; PD, progressive disease; SD, stable disease.