Table 5.

Logistic regression model for predictors of combined failure

Variable	Univariate analysis			Multivariate analysis
	ORs	95% CI	P value	ORs	95% CI	P value
EGFR mutation type (L858R vs. 19del)	0.990	(0.356, 2.751)	0.984
Age (≥ 65 vs. < 65)	1.285	(0.460, 3.586)	0.632
Sex (female vs. male)	0.347	(0.123, 0.978)	0.045	0.389	(0.135, 1.117)	0.079
Smoking history (yes vs. no)	0.547	(0.114, 2.621)	0.450
Best response evaluation (PR vs. SD)	0.735	(0.239, 2.260)	0.591
Best response evaluation (PD vs. SD)	0.681	(0.155, 2.997)	0.611
Initial Oligometastatic status (yes vs. no)	0.378	(0.115, 1.244)	0.110	0.439	(0.130, 1.477)	0.183
Initial CNS metastasis (yes vs. no)	1.111	(0.399, 3.093)	0.840
Treatment line (subsequent line vs. first line)	0.886	(0.312, 2.518)	0.820
Disease stage (IV vs. III)	0.584	(0.141, 2.415)	0.458

CNS, central nervous system; 95% CI, confidence interval; EGFR, epidermal growth factor rece,ptor; ORs, odds ratio; PR, partial response; PD, progressive disease; SD, stable disease.