Table 2.
Comparison of serum biomarkers in the training set
| Lymph Node Positive group (n = 231) | Lymph Node Negative group (n = 614) | t | P | |
|---|---|---|---|---|
| Ca724 (U/ml) | 39.41 ± 5.61 | 38.52 ± 5.56 | 2.083 | 0.038 |
| Ca199 (U/ml) | 50.65 ± 5.98 | 49.53 ± 5.12 | 2.533 | 0.012 |
| AFP (ng/ml) | 11.03 ± 2.11 | 10.64 ± 2.71 | 2.225 | 0.026 |
| CEA (ng/ml) | 20.65 ± 4.27 | 19.77 ± 4.23 | 2.677 | 0.008 |
| HGF (pg/ml) | 6.35 ± 2.21 | 5.92 ± 1.41 | 2.756 | 0.006 |
| VEGF (ng/L) | 368.32 ± 83.56 | 350.15 ± 87.14 | 2.732 | 0.006 |
| Transferrin saturation (%) | 27.94 ± 4.84 | 29.08 ± 4.24 | 3.173 | 0.002 |
| Ferritin (ng/ml) | 87.2 ± 24.25 | 91.47 ± 28.35 | 2.173 | 0.030 |
| sE-Selectin (ng/ml) | 44.56 ± 5.78 | 45.65 ± 5.29 | 2.597 | 0.010 |
| sICAM-1 (ng/ml) | 245.84 ± 32.78 | 237.37 ± 51.82 | 2.818 | 0.005 |
| IL-6 (pg/ml) | 1.57 ± 0.41 | 1.49 ± 0.26 | 2.846 | 0.005 |
| IL-8 (pg/ml) | 61.85 ± 5.65 | 60.69 ± 5.98 | 2.554 | 0.011 |
| cfDNA (ng/ml) | 103.54 ± 26.35 | 99.32 ± 25.86 | 2.105 | 0.036 |
CA724: Carbohydrate Antigen 72-4; CA19-9: Carbohydrate Antigen 19-9; AFP: Alpha-Fetoprotein; CEA: Carcinoembryonic Antigen; HGF: Hepatocyte Growth Factor; VEGF: Vascular Endothelial Growth Factor; sE-Selectin: Soluble E-Selectin; sICAM-1: Soluble Intercellular Adhesion Molecule-1; IL-6: Interleukin-6; IL-8: Interleukin-8; cfDNA: Cell-Free DNA.