Table 1.
Cancer cell lines characteristics
| Cell line | Histology* | Fhit status† | Apoptosis, %‡ |
|---|---|---|---|
| Lung | |||
| H460 | LCC | − | 53 |
| SK-MES | SQC | − | 39 |
| AFL | SCLC | − | 38 |
| POVD | SCLC | +/− | 10 |
| A549 | ADC | − | 46 |
| Calu-1 | SQC | − | 64 |
| Calu-3 | ADC | ++ | 6 |
| Cervical | |||
| SiHa | SQC | − | 24 |
| CaSki | SQC | ++ | 1 |
| Hela | ADC | − | 22 |
*
LCC, large cell carcinoma; SQC, squamous cell carcinoma; SCLC, small cell lung cancer; ADC, adenocarcinoma.
†
Endogenous Fhit expression by Western blot analysis: −, negative; +/−, weak positive; ++, strong positive.
‡
Percentage of cells showing apoptosis by TUNEL analysis 5 days after Ad5-Fhit transduction (representative result of experiments performed at least twice, in which standard deviation was less than 15%).