Skip to main content
. 2002 Mar 12;99(6):3657–3662. doi: 10.1073/pnas.022017899

Figure 2.

Figure 2

Impairment of yolk sac blood vessel formation in double NP knockout mouse embryos. (A) Yolk sac of E8.5 NP1−/−NP2−/− double knockout mouse. No blood vessels can be detected. (B and C) E10 yolk sacs of NP1−/−NP2+/+ and NP1+/+NP2−/− mice, respectively. Note presence of dense capillary plexus and large collection vessels (black arrow). (D) E10 yolk sac of NP1+/−NP2+/− control mouse. Note presence of dense capillary plexus with large collection vessels (black arrow). (E) E10 yolk sac of NP1+/−NP2−/− mouse embryo. Larger collecting vessels seem to be absent, and capillary density is very diminished. (F) E10 yolk sac of NP1−/−NP2+/− mouse. Blood vessel impairment is similar to that in E. The embryos in D and E (shown together) and F are littermates.