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[Preprint]. 2025 May 18:2025.05.14.654046. [Version 1] doi: 10.1101/2025.05.14.654046

Fig. 5: Netrin-1 expression in ADM and PanIN lesions in the human pancreas.

Fig. 5:

a, Uniform Manifold Approximation and Projection (UMAP) of all cells from single-nucleus RNA sequencing of two donors with chronic pancreatitis, with populations identified by color.

b, UMAP plot showing NTN1 expression in acinar, ductal, and tuft cell clusters.

c, Dot plot of NTN1 expression in acinar, ductal, and tuft cell clusters, where dot size represents the percentage of expressing cells and color indicates average expression levels.

d-h, Immunohistochemical analysis of Netrin-1 expression in histological sections from human PDAC patients, counterstained with hematoxylin. Normal (asymptomatic) tissue (d) and PanIN (f) were from a stage IB patient, while ADM (e) and PanIN (g,h) from peritumor tissues of stage III patients. Scale bar: 100 μm.