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Analysis of mutation rates in the cII gene of Big Blue fibroblasts ectopically expressing either wild-type ErbB2 [NEU2 (■), NEU3 (□), NEU pool (
)], activated ErbB2 [NT4 (▴)], or harboring vector alone (
). Only a single clone, NEU2, shows a consistent increase in mutant frequency.The expression was pJ4Ω (53).
