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. 2001 Jun 14;69(1):1–14. doi: 10.1086/321275

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© 2001 by The American Society of Human Genetics. All rights reserved.

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Decay of expected value of , as a function of genetic distance, for different growth models (sample size of 100 chromosomes). From top to bottom, the four models are as follows: constant population size of N_e=10⁴ (unbroken line); population-growth onset 500 generations ago—that is, 10⁴ years ago, under the assumption that there are 20 years per generation (dotted line); population-growth onset 5,000 generations ago (short-dashed line); and the model used by Kruglyak (1999) (see the “Model Predictions” section) (long-dashed line). In two growth models (dotted line and short-dashed line), the current population was fixed at 10⁵. Except in the Kruglyak model, the parameters were chosen to match the amount of genetic diversity seen in humans (see text). In each of 10⁴ simulations, 10 SNPs with a minor-allele frequency ⩾.2 were chosen.

Inline graphic — Decay of expected value of , as a function of genetic distance, for different growth models (sample size of 100 chromosomes). From top to bottom, the four models are as follows: constant population size of N_e=10⁴ (unbroken line); population-growth onset 500 generations ago—that is, 10⁴ years ago, under the assumption that there are 20 years per generation (dotted line); population-growth onset 5,000 generations ago (short-dashed line); and the model used by Kruglyak (1999) (see the “Model Predictions” section) (long-dashed line). In two growth models (dotted line and short-dashed line), the current population was fixed at 10⁵. Except in the Kruglyak model, the parameters were chosen to match the amount of genetic diversity seen in humans (see text). In each of 10⁴ simulations, 10 SNPs with a minor-allele frequency ⩾.2 were chosen.