Table 1.
Probability that a Locus is Polymorphic for Susceptibility Alleles[Note]
|
βN |
||||
| βS | .001 | .01 | .1 | 1.0 |
| A. No Selection |
||||
| .001 | .0046 | .0082 | .0080 | .0046 |
| .01 | .0082 | .0448 | .0729 | .0449 |
| .1 | .0080 | .0729 | .3593 | .3680 |
| .5 | .0058 | .0559 | .4247 | .8950 |
| 1.0 | .0046 | .0449 | .3680 | .9800 |
| 5.0 | .0026 | .0254 | .2309 | .9510 |
| 10.0 | .0019 | .0185 | .1755 | .9043 |
| B. Weak Purifying Selection (σ=12) |
||||
| .001 | .0017 | .0017 | .0017 | .0017 |
| .01 | .0173 | .0173 | .0173 | .0166 |
| .1 | .1656 | .1656 | .1650 | .1587 |
| .5 | .6332 | .6396 | .6387 | .6242 |
| 1.0 | .8410 | .8912 | .8956 | .8869 |
| 5.0 | .0319 | .2534 | .8241 | .9993 |
| 10.0 | .0049 | .0476 | .3781 | .9859 |
Note.— Probability that a locus is polymorphic for susceptibility alleles (i.e., that the frequency of S lies between .01 and .99); βS and βN give the scaled mutation rates to and from the susceptible class of alleles. Rough calculations suggest that, for most genes, βS will be in the range 0.1–5.0, and we can expect that the “repair” rate βN will typically be rather smaller: probably of the order of ⩽0.01.