Figure 2.

Three chromosomes typed for four marker loci, illustrating the relationship between the map distances of the markers, d={d₂,d₃,d₄}, and the disease-mutation location θ. In panel A, the mutation is to the left of all the markers; in panel B, it is to the right of all the markers; in panel C, it is flanked by markers to the left and markers to the right. The disease mutation is represented as an ellipse and is represented by “M” in panel A; the markers are represenetd as rectangles and are labeled as “1”–”4” in panel A.