Skip to main content
. 2001 Jun 12;69(1):49–54. doi: 10.1086/321282

Figure 2.

Figure 2

Locations of germline mutations and missense substitution, detected in the highly conserved SDHB coding sequence (HS = Homo sapiens; DM = Drosophila melanogaster). Multiple-sequence alignment was performed by the ClustalW program, available from BCM Search Launcher. The mutations are shown with respect to the functional domains of the protein, as predicted by the InterPro program. The black dots represent the four germline mutations described in the text. The yellow screen indicates the predicted ferredoxin domain (54–119 amino acids; GenBank accession number NP_002991), the green screen indicates the 2Fe-2S ferredoxin domain (93–101 amino acids), and the blue screen indicates the 4Fe-4S ferredoxin iron-sulfur–binding domain (186–197 amino acids).