Figure 4.

Haplotype analysis of the 6q25 region. In the table, a haplotype (indicated by gray shading) close to marker D6S264 is shown, for 19 affected individuals whose phase is known. Only the haplotype that is transferred from the pedigree (and not from the in-married parent) is shown. For the individuals in whom a marker was uninformative, the allele included in the haplotype is indicated by stippling. Both alleles are indicated for genotypes for which phase is unknown. Haplotypes from siblings are not separated by a vertical black line. The tale also shows, for each marker, the LOD score, the recombination fraction (θ), and the diagnosis that gave the MLS. The circles to the right of the table show allele frequencies in affected individuals and in the Swedish control population. Alleles that are represented in the haplotype are indicated by gray shading.