Table 4.
Immunologic Data
|
Statusa |
Immunoglobulin |
In Vitro Responses of Proliferation/INF-γ/TNF-α in Response toa,b |
|||||||
| Subject (Age [years]) | CMC | Thyroid Disease | Candida Skin Test | IgMc(mg/dl) | IgG(mg/dl) | IgA(mg/dl) | Mitogensd | Tetanus | Candida |
| II-4 (55) | + | + | − | 54 | 1,675 | 390 | ND | ND | ND |
| III-8 (22) | + | − | − | 51 | 1,405 | 192 | ND | ND | ND |
| III-9 (33) | − | − | ND | 80 | 954 | 104 | +/+/ND | +/+/+ | +/+/+ |
| IV-6 (12) | − | − | + | 37 | 851 | 47 | +/−/ND | +/+/+ | −/+/+ |
| IV-7 (11) | + | + | + | 29 | 938 | 41 | +/−/ND | −/−/+ | −/+/+ |
| IV-8 (10) | + | + | + | 37 | 1,003 | 71 | +/−/ND | −/−/+ | −/+/+ |
| IV-9 (8) | + | − | + | 34 | 1,039 | 118 | +/−/ND | −/−/+ | −/+/+ |
a
+ = Present; − = absent.
b
For INF-γ and TNF-α, data are for production in culture supernatants. ND = not done.
c
Mean ± SD normal IgM levels are as follows: 3–5 years, 56 ± 18; 6–8 years, 65 ± 25; 9–11 years, 79 ± 33; 12–16 years, 89 ± 20; adult, 99 ± 27 (Stiehm and Fudenberg 1966). Values >1 SD below the mean for age are underlined.
d
PHA, ConA, and PWM.