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. 2002 Mar 19;99(6):3818–3823. doi: 10.1073/pnas.062605899

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Copyright © 2002, The National Academy of Sciences

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Pdx-1^+/−/Hnf-3β^+/− and Pdx-1^+/−/Hnf-1α^+/− mice exhibit altered islet morphology. Immunofluorescent confocal microscopy of pancreatic islets of Wt (A), Hnf-3β^+/− (B), Hnf-1α^+/− (C), Pdx-1^+/− (D), Pdx-1^+/−/Hnf-3β^+/− (E), and Pdx-1^+/−/Hnf-1α^+/− (F) mice. Insulin-expressing cells are shown in red, glucagon-containing cells in green. Nuclei of respective cells are shown in blue. Islets from Pdx-1^+/−/Hnf-3β^+/− (E) and Pdx-1^+/−/Hnf-1α^+/− (F) mice show scattered α-cells throughout the islets. Pancreatic islet size was not significantly different in the different mutant mice.