Skip to main content
. 2002 Mar 19;99(6):3818–3823. doi: 10.1073/pnas.062605899

Figure 5.

Figure 5

Regulation of pancreatic islet transcription factors. Strong synergistic effects exist in vivo between Pdx-1, Hnf-1α, and Hnf-3β. Hnf-1α and Hnf-3β both regulate the expression of Pdx-1 in vivo and in vitro. Hnf-4α expression is normal in Hnf-4α+/− mutant mice, suggesting an autoregulatory feedback loop. Furthermore, Hnf-4α does not regulate the expression of Hnf-1α or Pdx-1 in pancreatic islets. Gene expression analysis also indicates that Nkx6.1 gene transcript levels are regulated by Pdx-1.