Table 4.
Two-Locus Conditional Analysis of IDDM Data Using the Ising Model
|
LOD Score (P) |
|||||
| Chromosome | Markera | Location(cM) | Single Locusb | Two Locus | Interaction |
| 1 | D1S229 | 238 | .003 (NS) | 1.43 (.02) | Negative |
| 2 | D2S301 | 215 | .0004 (NS) | 1.30 (.03) | Positive |
| 2 | D2S119 | 65 | .03 (NS) | 1.69 (.01) | Negative |
| 3 | D3S1560 | 19 | .09 (NS) | 1.50 (.02) | Negative |
| 3 | D3S1576 | 152 | 1.09 (.01) | 1.70 (.01) | Positive |
| 4 | D4S431 (D4S412) | 12 (5) | .90 (.02) | 1.57 (.02) | Negative |
| 6 | D6S294 | 79 | … | 2.26 (.0006)c | … |
| 7 | D7S519 | 69 | .09 (NS) | 1.17 (.03) | Negative |
| 8 | D8S281 (D8S257) | 125 (111) | .71 (.04) | 1.71 (.01) | Positive |
| 13 | D13S153 | 46 | .005 (NS) | 1.72 (.009) | Negative |
| 14 | D14S276 (D14S75) | 56 | .93 (.02) | 1.65 (.01) | Positive |
| 16 | D16S3098 | 108 | 3.16 (.00006) | 4.32 (.00002) | Positive |
| 21 | D21S219 | 34 | 0 (NS) | 1.22 (.03) | Negative |
The results shown are for selected loci where the two-locus conditional model is significant at the P<.05 level and where there is evidence (P<.05) for an interaction between the test locus and the conditional locus (HLA). In cases where the locations of the single-locus and two-locus maximum LOD scores are different, the location for the two-locus peak is indicated in parentheses.
NS = not significant.
This is a two-locus conditional LOD score with no additional interaction term. No interaction is necessary, since any genetic interaction between candidate genes is absorbed by the interaction terms due to linkage between markers. The resulting test is a one-sided LR test with 1 df.