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A, Coproporphyrin III/I ratio in samples of feces from the patient with the R401W heterozygous mutation. B, High-performance liquid chromatography of porphyrins in vitro from expression studies of this R401W mutation in E. coli. CI = coproporphyrin I; CIII = coproporphyrin III; P = protoporphyrin; H = harderoporphyrin; C = coproporphyrin.
