Table 4.
Evidence for Pleiotropic Influences of Specific Genetic Regions of Chromosome 6q on IRS-Related Phenotypes
|
Complete Pleiotropy |
Coincident Linkage |
||||
| Phenotype Pair | ρqa | Λb | pc | Λb | pd |
| Marker D6S403 region: | |||||
| FSI-BMI | 1 | .00 | .5000 | 13.74 | .0002 |
| FSI-SS | 1 | .00 | .4955 | 19.65 | <.0001 |
| FSI- LEPT | 1 | .00 | .4990 | 17.22 | <.0001 |
| FSI-ln TG | .8 | .23 | .3151 | 6.39 | .0115 |
| ln HOMA %S-BMI | −1 | .00 | .4877 | 13.25 | .0003 |
| ln HOMA %S-SS | −1 | .00 | .4972 | 18.94 | <.0001 |
| ln HOMA %S-LEPT | −1 | .00 | .4971 | 16.47 | <.0001 |
| ln HOMA %S-ln TG | −.6 | .84 | .1790 | 4.15 | .0416 |
| Marker D6S264 region: | |||||
| FSI-BMI | .9 | .93 | .1680 | 7.60 | .0059 |
| FSI-SS | 1 | .00 | .4901 | 15.25 | <.0001 |
| FSI-LEPT | .9 | .09 | .3844 | 16.77 | <.0001 |
| FSI-ln TG | .5 | 2.77 | .0479 | 3.44 | .0637 |
| ln HOMA %S-BMI | −.9 | .76 | .1917 | 7.91 | .0049 |
| ln HOMA %S-SS | −1 | .00 | .4942 | 15.26 | <.0001 |
| ln HOMA %S-LEPT | −.9 | .61 | .2172 | 16.73 | <.0001 |
| ln HOMA %S-ln TG | −.4 | 2.88 | .0450 | 3.44 | .0636 |
a
ρq is correlation due to QTL effects.
b
Likelihood-ratio statistic Λ.
c
Likelihood for a model in which ρq is estimated, compared with that of another model in which ρq is constrained to 1 (or −1) (i.e., complete pleiotropy). Λ is distributed as a ½χ21:½χ20 mixture.
d
Likelihood of a model in which ρq is estimated, compared with another model in which ρq is constrained to 0 (i.e., coincident linkage). Λ is distributed as a χ2 with df 1.