Table 3.

Microsatellite Marker Alleles Segregating with dHMN-VII in Families YH1 and P2^[Note]

		Disease-Linked Allele
Distance from p-tel(cM)	Marker	YH1	P2	Two-Point LOD Score in Combined Pedigree atθ=0
104	D2S2333	10	6	−3.01
111	D2S2216	6	3	−2.52
112	D2S2209	1	1	2.60
114	D2S2264a	3	3	4.51
115	D2S274	6	6	6.04
116	D2S2229	6	6	4.27
117	D2S1897	3	3	2.67
118	D2S293	3	3	4.96
120	D2S1890	4	4	3.56
122	D2S160	5	3	.19
124	D2S308	3	6	1.41
125	D2S437	4	5	.03
127	D2S2970	3	5	2.24
128	D2S100	4	4	6.33
129	D2S2265	4	4	1.12
130	D2S2224	1	1	1.92
131	D2S347	12	12	4.05
132	D2S2339	4	4	5.18
132	D2S275	4	4	6.63
132	D2S1273	8	8	2.03
132	D2S1272	11	11	3.19
133	D2S2271	1	1	3.97
133	D2S95	6	6	6.05
134	D2S2215a	9	9	2.84
137	D2S1260	9	9	5.36
141	D2S112	3	3	4.95
142	D2S2219	10	10	3.18
145	D2S1334	11	11	4.59
147	D2S2288	1	6	−3.06
152	D2S151	15	11	−6.34

Note.— The two intervals in which the disease-linked alleles in families YH1 and P2 are identical are shown in boxes. Genealogy investigations confirmed that the two families are related, and the most likely explanation for the interval between D2S1890 and D2S100, in which the disease-linked alleles differ, is a historic double recombination between the two families.

^aRecombinants at this marker in family YH1 (individuals IV:3 and V:7) define the minimal dHMN-VII interval.