Table 2.
Univariate and multivariate logistic regression analysis in the training sets of the two tasks
| Variables | Task 1 (grade 4 vs. GBM) | Task 2 (IDH-mut grade 4 vs. IDH-wt grade 4) | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | |
| Gender | 1.103(0.638–1.918) | 0.727 | 1.120 (0.458–2.729) | 0.802 | ||||
| Age(years) | 1.034 (1.013–1.056) | 0.002 | 1.028 (1.006–1.052) | 0.014 | 0.979 (0.948–1.009) | 0.170 | ||
| MGMTmet | 0.564 (0.316–0.991) | 0.049 | 0.503 (0.269–0.918) | 0.028 | 1.700 (0.612–5.247) | 0.326 | ||
| Treatment | 1.487 (0.856–2.585) | 0.159 | 0.831 (0.340–2.035) | 0.684 | ||||
| KPS | 0.987 (0.963–1.010) | 0.271 | 1.003 (0.967–1.044) | 0.863 | ||||
| Tumor number | 1.557 (0.903–2.706) | 0.113 | 0.673 (0.244–1.745) | 0.426 | ||||
| Tumor margin | 0.971 (0.561–1.676) | 0.917 | 1.167 (0.465–3.032) | 0.745 | ||||
| Intratumoral hemorrhage | 1.776 (0.925–3.555) | 0.093 | 0.940 (0.268–2.959) | 0.918 | ||||
| Intratumoral necrosis | 1.696 (0.867–3.308) | 0.120 | 1.643 (0.617–4.752) | 0.335 | ||||
| Peritumoral edema | 5.480 (1.581–25.261) | 0.013 | 1.960 (0.424–10.969) | 0.405 | 2.625 (0.621–18.028) | 0.238 | ||
| Maximum diameter | 1.062 (0.915–1.238) | 0.432 | 0.888 (0.699–1.118) | 0.316 | ||||
| Midline shift | 0.972 (0.565–1.671) | 0.918 | 1.184 (0.488–2.895) | 0.709 | ||||
| Enhancement pattern | 1.465 (1.117–1.944) | 0.006 | 1.085 (0.765–1.552) | 0.649 | 1.492 (0.966–2.348) | 0.075 | ||
| Enhancement quality | 4.333 (1.97–10.127) | <0.001 | 2.568 (0.832–8.27) | 0.105 | 1.396 (0.518–4.067) | 0.521 | ||
| TCM | 1.387 (0.692–2.752) | 0.350 | 0.733 (0.264–2.113) | 0.555 | ||||
| ECM | 1.462 (0.756–2.804) | 0.254 | 0.338 (0.129–0.866) | 0.025 | 0.211 (0.067–0.602) | 0.005 | ||
| Cortical involvement | 0.892 (0.496–1.621) | 0.705 | 1.400(0.526–3.651) | 0.493 | ||||
| Deep white matter invasion | 1.024 (0.562–1.894) | 0.939 | 3.594 (1.344–9.956) | 0.012 | 5.688 (1.912–18.609) | 0.003 | ||
| Pial invasion | 1.423 (0.822–2.465) | 0.208 | 2.217 (0.909–5.575) | 0.084 | ||||
| Ependymal invasion | 1.350 (0.725–2.496) | 0.340 | 2.333 (0.857–7.121) | 0.112 | ||||
GBM glioblastoma, IDH-mut Isocitrate dehydrogenase-mutant, IDH-wt Isocitrate dehydrogenase wild-type, OR odds ratio, CI confidence interval, MGMTmet methyl guanine methyl transferase promoter methylation, KPS karnofsky performance status score, TCM tumor crosses midline, ECM edema crosses midline