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. 2005 May 18;77(1):140–148. doi: 10.1086/431425

Table 3.

Association of AGA with Markers at the AR Locus[Note]

Frequency
 TDTa
 Affected/Control Analysis
 Affected/Unaffected Analysis
SNP andAllele Affected Control Unaffected Transmitted Nontransmitted Pc P ORd CI P ORd CI Positionb
rs12560201: 6.68 × 10−1 8.99 × 10−1 1.04 .55–1.82 9.38 × 10−1 .97 .5–1.87 63,335,397
 G .112 .108 .115 23 27
 A .888 .892 .885
rs1332720: 1.00 1.00 ND ND 1.00 ND ND 64,598,557
 C .995 1.000 1.000 0 1
 T .005 .000 .000
rs1044165: 1.00 9.50 × 10−1 .98 .55–1.89 1.58 × 10−1 1.53 .85–2.76 65,024,747
 A .124 .122 .178 22 23
 G .876 .878 .822
rs708969: 5.35 × 10−1 1.21 × 10−2 2.02 1.16–3.53 3.90 × 10−3 2.27 1.29–4 65,252,916
 A .875 .776 .755 36 29
 T .125 .224 .245
rs1379146: 3.25 × 10−1 2.68 × 10−4 2.61 1.55–4.45 4.72 × 10−4 2.60 1.51–4.5 65,389,382
 T .872 .723 .724 39 29
 A .128 .277 .276
rs1158928: 1.30 × 10−1 1.04 × 10−5 3.23 1.89–5.56 2.08 × 10−5 3.22 1.85–5.61 65,532,217
 A .883 .700 .701 42 27
 G .117 .300 .299
rs1485682: 1.30 × 10−1 1.97 × 10−5 3.13 1.82–5.35 3.08 × 10−5 3.16 1.81–5.48 65,598,612
 C .883 .707 .705 42 27
 T .117 .293 .295
rs1385699: 1.22 × 10−1 1.60 × 10−5 3.23 1.86–5.59 9.41 × 10−5 3.00 1.71–5.32 65,608,007
 A .887 .708 .722 44 28
 G .113 .292 .278
rs1385695: 2.97 × 10−3 1.03 × 10−5 4.68 2.24–9.78 2.40 × 10−8 6.57 3.17–13.63 65,687,533
 A .949 .799 .739 38 13
 G .051 .201 .261
rs775362: 4.10 × 10−3 2.09 × 10−5 4.39 2.13–9.21 3.73 × 10−8 6.40 3.11–13.39 65,762,194
 G .949 .809 .744 37 13
 A .051 .191 .256
rs1041668: 1.49 × 10−4 1.80 × 10−6 6.42 2.74–15.03 1.58 × 10−9 9.29 4.03–21.44 65,868,977
 G .036 .194 .258 9 39
 A .964 .806 .742
rs5964577: 2.50 × 10−3 4.24 × 10−6 4.99 2.32–10.68 1.20 × 10−8 7.02 3.29–15.08 65,954,512
 A .954 .806 .747 36 12
 T .046 .194 .253
rs532649: 5.96 × 10−6 5.42 × 10−7 6.38 2.75–14.71 2.33 × 10−10 9.62 4.17–22.13 66,050,269
 A .960 .807 .735 37 7
 G .036 .193 .265
rs989345: 4.65 × 10−6 1.60 × 10−6 6.24 2.74–14.66 6.13 × 10−10 9.56 4.2–22.29 66,084,055
 A .964 .811 .737 36 6
 G .036 .189 .263
rs938059: 4.03 × 10−6 1.10 × 10−6 6.55 2.82–15.25 9.20 × 10−10 9.63 4.18–22.17 66,119,748
 C .036 .195 .263 7 40
 A .964 .805 .737
rs925391: 4.76 × 10−6 5.97 × 10−7 7.28 3.03–18.03 1.98 × 10−10 11.15 4.65–27.42 66,123,458
 G .969 .811 .737 38 6
 A .031 .189 .263
rs5919287: 4.62 × 10−6 2.57 × 10−7 6.61 2.87–12.82 1.76 × 10−10 9.70 4.22–22.45 66,143,635
 C .964 .802 .734 39 7
 T .036 .198 .266
rs2221799: 4.62 × 10−6 3.37 × 10−7 6.53 2.84–15.18 1.39 × 10−9 9.21 4.04–21.47 66,159,637
 A .964 .804 .744 39 7
 G .036 .196 .256
rs10521339: 4.00 × 10−4 1.95 × 10−7 5.65 2.65–12.04 2.10 × 10−12 9.89 4.62–20.7 66,291,407
 A .954 .778 .677 11 41
 T .046 .212 .323
rs2223841: 9.40 × 10−6 1.20 × 10−6 5.59 2.62–11.94 1.72 × 10−11 9.48 4.48–20.05 66,353,192
 A .954 .789 .688 44 11
 G .046 .211 .312
rs2207081: 4.33 × 10−6 7.00 × 10−7 6.21 2.8–13.78 5.04 × 10−12 10.72 4.89–23.75 66,356,719
 A .959 .792 .688 44 10
 G .041 .208 .312
rs2497935: 1.79 × 10−5 3.10 × 10−6 5.00 2.41–10.36 3.17 × 10−11 8.69 4.23–17.87 66,447,287
 A .949 .790 .684 45 12
 G .041 .208 .316
rs962458: 2.89 × 10−3 2.87 × 10−4 7.32 2.12–25.3 2.56 × 10−6 11.10 3.27–37.74 66,528,985
 G .015 .102 .146 2 17
 A .985 .898 .854
CAGe: 2.71 × 10−1 f 66,548,181
 18 .042 .085 .110 13 12 NS ND ND NS ND ND
 19 .110 .106 .110 30 39 NS ND ND NS ND ND
 20 .194 .112 .103 50 19 2.66 × 10−2 1.91 1.07–3.41 2.20 × 10−2 2.10 1.10–3.99
(continued)
 21 .147 .191 .205 32 31 NS ND ND NS ND ND
 22 .136 .122 .096 32 28 NS ND ND NS ND ND
 23 .126 .090 .068 26 30 NS ND ND NS ND ND
 24 .084 .080 .096 19 36 NS ND ND NS ND ND
 25 .047 .064 .075 12 14 NS ND ND NS ND ND
rs6152: 5.88 × 10−5 3.80 × 10−6 5.26 2.45–11.3 6.66 × 10−10 8.21 3.86–17.45 66,548,648
 T .046 .201 .282 11 40
 C .954 .799 .718
GGNe: 7.79 × 10−5 f 66,549,360
 23 .651 .495 .421 76 43 2.06 × 10−3 1.91 1.26–.2.88 2.07 × 10−5 2.57 1.656–3.98
 24 .182 .367 .461 21 68 5.39 × 10−5 .38 .24–.62 2.62 × 10−8 .26 .161–.42
rs1204038: 9.79 × 10−5 1.90 × 10−6 5.45 2.55–11.67 2.83 × 10−9 7.72 3.62–16.46 66,571,246
 A .046 .208 .271 11 39
 G .954 .792 .729
rs5919393: 1.58 × 10−5 6.00 × 10−7 5.82 2.73–12.41 1.69 × 10−8 7.88 3.7–16.77 66,608,378
 C .046 .218 .274 11 38
 T .954 .782 .726
rs1337080: 5.73 × 10−3 6.71 × 10−4 6.73 1.92–23.14 4.75 × 10−6 10.78 3.12–36.19 66,661,940
 A .985 .907 .859 15 2
 G .015 .093 .141
XARx7_001g: 1.00 6.79 × 10−2 3.95 .81–19.25 1.45 × 10−1 3.21 .61–16.76 66,725,646
 A .010 .039 .032 3 3
 G .990 .961 .968
XARx8insAh: 3.29 × 10−3 5.09 × 10−5 4.11 1.99–8.47 6.62 × 10−8 5.94 2.94–12.02 66,727,141
 delA .944 .804 .739 34 13
 A .056 .196 .261
rs2781516: 3.28 × 10−2 1.00 × 10−2 2.02 1.18–3.48 2.86 × 10−4 2.69 1.56–4.64 66,885,052
 A .128 .228 .282 21 38
 G .872 .772 .718
rs2885913: 4.46 × 10−2 1.49 × 10−4 2.31 1.49–3.57 4.29 × 10−5 2.53 1.62–3.97 66,898,824
 G .255 .441 .465 40 64
 A .745 .559 .535
rs2363785: 1.73 × 10−2 1.82 × 10−4 2.28 1.47–3.53 2.04 × 10−4 2.34 1.49–3.68 66,954,319
 G .745 .562 .555 65 37
 T .255 .438 .445
rs1936313: 2.48 × 10−2 7.91 × 10−5 2.37 1.54–3.64 9.15 × 10−4 2.15 1.36–3.37 66,983,669
 T .744 .551 .575 65 39
 C .256 .449 .425
rs492933: 2.44 × 10−2 1.15 × 10−2 1.76 1.13–2.72 2.39 × 10−2 1.69 1.07–2.65 67,046,865
 C .736 .614 .623 67 40
 T .264 .386 .377
rs1410127: 2.83 × 10−2 8.02 × 10−3 1.79 1.16–2.76 2.13 × 10−2 1.71 1.08–2.67 67,063,402
 C .735 .608 .619 66 40
 T .265 .392 .381
rs1157321: 7.83 × 10−4 1.59 × 10−5 2.89 1.75–4.7 2.73 × 10−5 2.93 1.75–4.87 67,104,762
 G .848 .659 .656 64 27
 T .152 .341 .344
rs7887862: 1.09 × 10−1 3.31 × 10−1 1.34 .74–2.41 1.28 × 10−1 1.65 .86–3.2 67,148,136
 C .152 .118 .098 36 21
 T .848 .882 .902
rs1927232: 6.77 × 10−1 1.77 × 10−1 1.36 .87–2.11 8.23 × 10−1 1.06 .66–1.69 67,165,912
 C .719 .653 .708 49 44
 T .281 .347 .292
rs5965536: 1.56 × 10−1 3.57 × 10−1 1.33 .73–2.41 9.50 × 10−1 1.02 .57–1.84 67,300,796
 C .154 .121 .151 35 24
 G .846 .879 .849
rs792952: 1.39 × 10−1 8.45 × 10−1 1.05 .65–1.69 8.56 × 10−1 1.05 .64–1.71 67,766,144
 C .249 .240 .240 53 36
 G .751 .760 .760

Note.— ND = not determined; NS = not significant.

a

Family transmission/disequilibrium test (Knapp and Becker 2003).

b

UCSC Genome Bioinformatics Plus Strand Build 35.

c

Permutation-based value for association.

d

Odds ratio.

e

Only alleles with frequencies ⩾0.05 in controls.

f

Global P value.

g

GCTTTGTCTAATGCTCCTTC[G/A]TGGGCATGCTTCCCCTCCCC (intron 6 of AR).

h

ACAAGCAAACAAAAAAAAAA[A/delA]GCAAAAACAAAACAAAAAAT (exon 8 of AR).