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. 2005 May 3;77(1):16–26. doi: 10.1086/431216

Figure 3.

Figure 3

Schematic model of the reduced-folate transporter family. SLC19A3 encodes a predicted protein containing 12 putative transmembrane domains. The relative positions of the mutations identified in SLC19A3 in patients with BBGD and of the missense and nonsense mutations in SLC19A2, reported in patients with Rogers syndrome, are shown (Diaz et al. 1999; Labay et al. 1999; Raz et al. 2000; Scharfe et al. 2000; Lagarde et al. 2004). The positions of mutations in SLC19A2 were assigned in accordance with hydrophobicity plots that were determined by HMMTOP 2.0 (Tusnady and Simon 1998, 2001). SLC19A2 and SLC19A3 (NCBI accession numbers NP_008927 and NP_079519) were used for analysis.