Table 1.
Table of genes deregulated by loss of E2F1 in C3H/HeJ mice
| Accession no. | Entrez definition | Fold change |
|---|---|---|
| mRNAs that decrease in the absence of E2F1 | ||
| L27121 | Mus musculus (10-1) hydroxysteroid sulfotransferase (mSTa2) mRNA, complete cds | 21.1 |
| M88694 | M. musculus thioether S-methyltransferase mRNA, complete cds | 9.7 |
| M77497 | M. musculus cytochrome P-450 naphthalene hydroxylase mRNA, complete cds | 4.4 |
| M77015 | Mouse 3-β-hydroxysteroid dehydrogenase/delta-5-δ-4-isomerase mRNA sequence | 3.9 |
| D00926 | Mouse mRNA for transcription factor S-II-related protein | 3.7 |
| D45850 | Mouse mRNA for estradiol 17-β-dehydrogenase (A-specific), complete cds | 3.4 |
| X83202 | M. musculus mRNA for 11-β-hydroxysteroid dehydrogenase/carbonyl reductase | 3.3 |
| M57960 | Mouse carboxylesterase mRNA, complete cds | 3.2 |
| X70398 | Mouse pentylenetetrazol-related mRNA PTZ-17 | 3.2 |
| L10106 | M. musculus protein tyrosine phosphate mRNA, complete cds | 3.1 |
| NM_019646 | M. musculus eukaryotic translation initiation factor 3, subunit 8 | 3.1 |
| mRNAs that increase in the absence of E2F1 | ||
| M12347 | Mouse mRNA for skeletal muscle α-actin | 3.4 |
| M73490 | M. musculus apolipoprotein E mRNA, 3′ end | 3.5 |
| M63660 | Mouse G-α-13 protein mRNA, complete cds | 3.5 |
| M34398 | M. musculus loricrin gene, complete cds | 3.8 |
| M33960 | Mouse PAI-1 mRNA, complete cds | 5.7 |
| NM_016908 | M. musculus synaptotagmin 5 (Syt5) mRNA | 6.4 |
Listed are the genes that showed the greatest response to the loss of E2F1 in the experiment shown in Fig. 2B. mRNAs that decrease in the absence of E2F1 are those which require E2F1 for high level expression; mRNAs that increase in the absence of E2F1 are those which are normally repressed by E2F1.