Table 7.
Association of CRP Haplotypes with Plasma CRP Level at Year 7[Note]
| Variable | tagSNP Alleles | Haplotype Frequencya | Coefficient | SE | t | P |
| Intercept | … | … | −8.0161 | .0703 | … | … |
| EA | … | … | −.0332 | .0502 | −.661 | .509 |
| Male | … | … | −1.0083 | .1817 | −5.549 | <.00001 |
| ln(BMI) | … | … | 2.4367 | .1008 | 24.18 | <.00001 |
| ln(insulin) | … | … | .1963 | .0511 | 3.845 | .00012 |
| ln(triglycerides) | … | … | −.2996 | .0722 | −4.151 | .00003 |
| Current smoker | … | … | .7819 | .1406 | 5.561 | <.00001 |
| H1 | ACACCAA | .0381 | −.1262 | .0728 | −1.734 | .0831 |
| H2 | ACAGCAA | .2306 | Referent | … | … | … |
| H3 | ACAGCGA | .0398 | .1387 | .0725 | 1.912 | .056 |
| H4 | ACAGCGG | .2215 | .0563 | .0393 | 1.432 | .152 |
| H5 | ATTGCGA | .2053 | .2818 | .0398 | 7.085 | <.00001 |
| H6 | TTAGCGA | .0717 | .4498 | .0592 | 7.602 | <.00001 |
| H7 | AAAGCGA | .0481 | .3128 | .0669 | 4.677 | <.00001 |
| H8 | AAAGAGA | .0948 | .1749 | .054 | 3.236 | .00122 |
| Otherb | … | .0502 | .1908 | .0705 | 2.706 | .00685 |
| Sex × ln(triglycerides) | … | … | .367 | .0441 | 8.324 | <.00001 |
| Sex × smoking | … | … | −.3587 | .0877 | −4.091 | .00004 |
Note.— t statistics and P values were calculated from the coefficients and SEs within the best-fit multivariate model by the haplo.glm function of the haplo.stats R package.
a
Haplotype frequencies were inferred using the EM algorithm within the haplo.stats package.
b
Haplotypes with frequency <1% were pooled as “Other.”