Table 8.
Association of CRP Haplotypes with Plasma CRP Level at Year 15[Note]
| Variable | tagSNP alleles | Haplotype Frequencya | Coefficient | SE | t | P |
| Intercept | … | … | −7.1203 | .0745 | … | … |
| EA | … | … | −.0405 | .0495 | −.819 | .413 |
| Male | … | … | −1.69 | .1824 | −9.265 | <.00001 |
| ln(BMI) | … | … | 2.4717 | .0963 | 25.657 | <.00001 |
| ln(insulin) | … | … | .2016 | .0438 | 4.605 | <.00001 |
| ln(triglycerides) | … | … | −.4544 | .0671 | −6.771 | <.00001 |
| Current smoker | … | … | .7411 | .1456 | 5.09 | <.00001 |
| H1 | ACACCAA | .0378 | −.2275 | .0717 | −3.172 | .00153 |
| H2 | ACAGCAA | .2262 | Referent | |||
| H3 | ACAGCGA | .0414 | −.0335 | .0706 | −.475 | .635 |
| H4 | ACAGCGG | .2231 | .0534 | .0386 | 1.381 | .167 |
| H5 | ATTGCGA | .205 | .2125 | .0391 | 5.437 | <.00001 |
| H6 | TTAGCGA | .0733 | .5219 | .0573 | 9.107 | <.00001 |
| H7 | AAAGCGA | .0475 | .3152 | .066 | 4.778 | <.00001 |
| H8 | AAAGAGA | .096 | .2044 | .0531 | 3.851 | .00012 |
| Otherb | … | .0496 | .1552 | .0725 | 2.142 | .0323 |
| Sex × ln(triglycerides) | … | … | .4801 | .0418 | 11.487 | <.00001 |
| Sex × smoking | … | … | −.3583 | .0914 | −3.918 | .00009 |
Note.— t statistics and P values were calculated from the coefficients and SEs within the best-fit multivariate model by the haplo.glm function of the haplo.stats R package.
a
Haplotype frequencies were inferred using the EM algorithm within the haplo.stats package.
b
Haplotypes with frequency <1% were pooled as “Other.”