Table 1.
The PDT and geno-PDT Association Analyses of GABA Genes and Autism
|
Global P fora |
|||
| Chromosome,Gene, and SNP | Marker Number | PDTb | geno-PDTc |
| Chromosome 4: | |||
| GABRG1: | |||
| RS1497571 | 1 | .899 | .906 |
| RS2350439 | 2 | .509 | .717 |
| RS1826923 | 3 | .340 | .622 |
| GABRA2: | |||
| HCV7537166 | 4 | .556 | .778 |
| RS279858 | 5 | .361 | .623 |
| RS279844 | 6 | .138 | .294 |
| HCV8262290 | 7 | .064 | .141 |
| RS4695152 | 8 | .508 | .730 |
| HCV8262334 | 9 | .149 | .033 |
| GABRA4: | |||
| RS7678338 | 10 | .737 | .936 |
| RS1512136 | 11 | .935 | .996 |
| HCV1592545 | 12 | 1.000 | .968 |
| RS1912960 | 13 | .012 | .003 |
| RS2280073 | 14 | .072 | .034 |
| RS10517174 | 15 | .738 | .142 |
| RS3792211 | 16 | .677 | .391 |
| GABRB1: | |||
| RS2351299 | 17 | .817 | .098 |
| RS1372496 | 18 | .088 | .160 |
| RS3114084 | 19 | .180 | .317 |
| HCV11353524 | 20 | .115 | .243 |
| HCV2119841 | 21 | .906 | .432 |
| RS6289 | 22 | .544 | .276 |
| RS6290 | 23 | .940 | .506 |
| Chromosome 5: | |||
| GABRB2: | |||
| RS253017 | 24 | .774 | .317 |
| RS252965 | 25 | .649 | .299 |
| RS2617503 | 26 | .108 | .025 |
| RS2962425 | 27 | .367 | .443 |
| RS2962407 | 28 | .771 | .149 |
| RS12187676 | 29 | .407 | .015 |
| GABRA6: | |||
| RS3811995 | 30 | .613 | .488 |
| RS6883829 | 31 | .932 | .236 |
| HCV164095 | 32 | .814 | .920 |
| RS3811991 | 33 | .652 | .283 |
| GABRA1: | |||
| RS4340950 | 34 | .426 | .650 |
| HCV11258504 | 35 | .633 | .601 |
| RS6878494 | 36 | .395 | .699 |
| HCV1667770 | 37 | .861 | .522 |
| HCV11814555 | 38 | .294 | .576 |
| GABRG2: | |||
| RS7728001 | 39 | .670 | .833 |
| RS766349 | 40 | .700 | .223 |
| RS211014 | 41 | .655 | .815 |
| GABRP: | |||
| HCV3165046 | 42 | .872 | .779 |
| RS1812910 | 43 | .965 | .981 |
| RS1862242 | 44 | .347 | .593 |
| RS1063310 | 45 | .560 | .807 |
| Chromosome 6: | |||
| GABRR1: | |||
| RS404943 | 46 | .619 | .674 |
| RS407206 | 47 | .623 | .835 |
| RS423463 | 48 | .475 | .718 |
| RS3777530 | 49 | .644 | .831 |
| RS2297389 | 50 | .851 | .150 |
| RS881293 | 51 | .832 | .978 |
| RS6902106 | 52 | .829 | .712 |
| GABRR2: | |||
| RS282117 | 53 | .277 | .494 |
| HCV9866022 | 54 | .064 | .171 |
| RS2148174 | 55 | .855 | .770 |
| HCV9865968 | 56 | .780 | .962 |
| Chromosome 15: | |||
| GABRB3: | |||
| RS2081648 | 57 | .602 | .837 |
| RS1426217 | 58 | .191 | .305 |
| RS754185 | 59 | .672 | .852 |
| HCV8865209 | 60 | .337 | .521 |
| RS2059574 | 61 | .304 | .405 |
| GABRA5: | |||
| HCV42974 | 62 | .646 | .072 |
| RS7173260 | 63 | .938 | .845 |
| RS140681 | 64 | .886 | .762 |
| RS140683 | 65 | .825 | .978 |
| GABRG3: | |||
| HCV2078506 | 66 | .079 | .240 |
| RS208129 | 67 | .281 | .266 |
| RS897173 | 68 | .240 | .451 |
| HCV428306 | 69 | 1.000 | .611 |
| RS140679 | 70 | .410 | .589 |
a
P values <.05 are shown in bold italics.
b
P values adjusted for two alleles.
c
P values adjusted for three genotypes.