Figure 4.

ATLa enhances BPI-dependent bacterial killing. Adherent Caco2 cells were incubated with vehicle or indicated concentrations of ATLa (24 h) and the role of BPI in Caco2 killing of S. typhimurium over a 60-min period was assessed. (A) Concentration-dependent increases in bacterial killing with previous exposure to ATLa. (Inset) A killing curve in the absence of ATLa. (B) Relative contribution of BPI was examined by incubation anti-BPI or control antisera preadsorbed with rBPI. Shown here are pooled results from three experiments. (**, indicates significantly different from control condition; P < 0.01)