Skip to main content
. Author manuscript; available in PMC: 2006 Jun 15.
Published in final edited form as: J Neurosci Res. 2005 Jun 15;80(6):798–808. doi: 10.1002/jnr.20474

Fig. 1.

Fig. 1

Regions showing reduced Cx43 in spinal cords from mice with EAE correlate with monocytes and dystrophic axons. Confocal microscopic images depicting transverse lumbar spinal cord sections from controls and two mice with EAE that were triply labeled for Cx43 (a–c; green), SMI32 (d–f; red), and CD11β (g–i; blue). Merged images are shown in j–l. Control tissue (left row) has intense Cx43 labeling but does not display SMI32 (dystrophic axons) and CD11β (monocytes) labeling. Tissue from animals sick with EAE (middle and right rows) has pockets of reduced Cx43 immunoreactivity. These regions also show increased axonal dystrophy and monocyte infiltration, indicated by enhanced SMI32 and CD11β labeling, respectively. A region clear of CD11β within an inflammatory compartment displays preserved Cx43 labeling (arrow). Scale bar = 50 μm.