Figure 2.

Spontaneous calcium oscillations in neural progenitors. Migrating neural progenitors derived from WT (A, C) and Cx43-null (B, D) mice exhibit spontaneous intracellular calcium transients that were greatly attenuated by bath application (arrow) of apyrase (A, B). Removal of extracellular calcium did not appreciably affect the amplitude of either long- or short-duration calcium oscillations in WT cells (C) but greatly reduced the amplitude of Ca²⁺ oscillations in Cx43-null progenitor cells (D). Black and gray traces were simultaneously recorded from two cells.