Figure 5.

Contribution of P2Y₁ receptors during neural progenitor migration. Top, Phase-contrast images of the migration of WT and Cx43-null progenitors after 3 d of culture. The correspondent OI is indicated in each image. Scale bar, 95 μm. Bottom, Time course of this migration as evaluated by the outgrowth index in the absence (untreated) and presence of P2R antagonists (100 μm; suramin, MRS-2179, and suramin plus MRS-2179). Note that both P2R antagonists significantly reduced (^*p < 0.0001; ANOVA) the outgrowth index of WT neural progenitors to levels that were similar to those obtained for Cx43-null cells.