Figure 6.

Comparison of endogenous NSC populations in reeler and wild-type mice (×100). BrdUrd incorporated into the nuclei of proliferating cells was detected by fluorescent immunohistochemistry (red), and all of the nuclei were counterstained with DAPI (blue). (Upper) Dramatically decreased population of stem cells in the hippocampus of homozygous (a) and heterozygous (b) reeler mice compared with wild-type mice (c). (Lower) Similar population of stem cells in the SVZ of homozygous reeler (d) and wild-type mice (e). Note the unorganized structure of the dentate gyrus in homozygous reeler mice (a). Nuclei were counterstained with DAPI (blue).