Figure 5.

Enhanced spatial memory in S100B-null mice. No difference was observed between genotypes in the escape latencies in water maze training (wild-type, n = 18; heterozygous, n = 19; mutant, n = 19) in the hidden-platform task (A) and the visible-platform task (B). (C) The probe test after the acquisition of the hidden-platform task. Times spent in each quadrant of the pool are shown. Mutant mice had a tendency to spend longer time in the trained quadrant than did the other genotypes (P = 0.097). (D) Number of crosses over the region where the platform had been located during the probe test. Mutant mice crossed the point significantly more than any other genotypes (P < 0.05). (E) Swimming path length during the probe test was not different between genotypes. Data represent mean ± SE. *, P < 0.05.