Table 3.
Salivary cortisol concentrations before and after three months of GAHT.
| Transmasculine group |
Transfeminine group |
|||||
|---|---|---|---|---|---|---|
| n = 11 |
n = 7 |
|||||
| Baseline | Three months of GAHT | Three months vs. baseline | Baseline | Three months of GAHT | Three months vs. baseline | |
| Absolute cortisol levels (hours after awakening) | ||||||
| T1: + 0.5 h (nmol/L) | 11.2 (6.9) | 12.1 (7.9) | p = 0.82 | 6.3 (3.2) | 8.9 (5.2) | p = 0.25 |
| T2:+ 5.5 h (nmol/L) | 2.5 (1.1) | 3.0 (2.4) | P = 0.59 | 1.7 (0.7) | 2.5 (1.1) | P = 0.06 |
| T3:+ 10.5 h (nmol/L) | 1.5 (1.2) | 1.3 (1.2) | P = 0.63 | 2.4 (2.4) | 3.1 (2.3) | p = 0.52 |
| T4: 0.5 h before bedtime (nmol/L) | 0.7 (0.5) | 1.1 (1.5) | P = 0.12 | 0.4 (0.2) | 0.9 (0.8) | P = 0.40 |
| Total daily cortisol | ||||||
| Daily Average Cortisol (nmol/L) | 4.0 (2.1) | 4.4 (2.7) | P = 0.77 | 2.7 (0.9) | 3.8 (1.8) | P = 0.15 |
| Area Under the Curve (nmol/La hours) | 50.5 (25.1) | 50.5 (31.4) | p = 0.85 | 36.8 (14.3) | 50.6 (23.3) | P = 0.13 |
| Cortisol slope | ||||||
| Wake-Bedtime slope (nmol/L) | −10.6 (6.6) | −11.0 (6.8) | p = 0.90 | −5.9 (3.2) | −8.0 (4.8) | p = 0.30 |
| Linear diurnal slopea (nmol/Lahours) | −1.9 (−2.5 to −1.3), p < 0.001 | −2.2 (−3.0. to −1.4), p < 0.001 | −0.2 (−0.8 to 1.3), p = 0.67 | −0.8 (−1.4 to −0.2), p = 0.02 | −1.3 (−1.9 to −0.6), p < 0.001 | 0.5 (−0.4 to 1.4), p = 0.29 |
| Quadratic diurnal slopea (nmol/La hours2) | 0.08 (0.04–0.12) P = 0.001 |
0.09 (0.04–0.14) P < 0.001 |
0.01 (−0.8 to 0.05), p = 0.70 | 0.03 (−0.01 to 0.06), p = 0.19 | 0.05 (0.01–0.09), p = 0.03 | 0.02 (−0.08 to 0.03), p = 0.41 |
a
Analyzed in one model with both linear and quadratic slopes. The cells in the Baseline and Three months of GAHT columns display the means and standard deviations of the outcomes, except for the cells displaying the linear and diurnal slope, which display the estimated slope. Cells in the Three months vs. Baseline columns display the results of statistical analyses comparing the two time points.