Fig. 9. Mechanism of action of hyperforin as an antidepressant.631It inhibits the uptake of 5-HT and DA and inhibits GABA, AMPA and NMDA. 2It inhibits neurotransmitter uptake by activating TRPC6. 3It works by activating BDNF and hence enhances learning ability and memory in rats. 4It shows increased expression of TrkB with mobilisation of intracellular calcium. 5Its protonophoric activity increases the intracellular concentration of sodium and increases the expression of TrkB.
