Figure 3.

Wortmannin and LY294002 reduce ICP increases elicited by electrical stimulation of the cavernous nerve. (a) Representative ICP responses for individual rats stimulated 10 min after intracavernosal injection of wortmannin (260 ng), LY294002(900 ng), or DMSO alone (0.15%). The stimulus interval is indicated by a solid bar. (b) Mean maximal ICP, total ICP, and tumescence slope calculated for rats treated with the indicated doses of wortmannin (left side) or LY294002 (right side). The slope and area under the curve were calculated from ICP recordings normalized to mean arterial pressure (MAP). Each bar depicts the mean ± SE for n = 7 (wortmannin) or 8 (LY294002) animals. *, P < 0.05 vs. vehicle alone by ANOVA.