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Increased ICP after intracavernous papaverine injection (PAP) is reduced by PI3-kinase inhibitors. (a) Representative ICP tracings for erections elicited in rats by 1.5 mg of papaverine 10 min after intracavernous injection of wortmannin (WORT, 260 ng), LY294002 (LY, 900 ng), or DMSO alone (0.15%). (b) Mean ± SE for maximal ICP of the indicated number of animals in each treatment group. *, P < 0.05 vs. DMSO alone by ANOVA.
