Figure 5.

eNOS^−/− mice show decreased erectile response to papaverine injection (PAP) compared with wild-type and nNOS^−/− animals. (a) Representative ICP tracings showing 0.4 mg of papaverine's effect on ICP in individual mice. Injection of papaverine is indicated, with elevation of ICP occurring ≈5 min later. (b) Mean ± SE for maximal ICP response in wild-type, eNOS^−/−, and nNOS^−/− mice after intracavernous injection of papaverine. The number of animals tested is indicated in each bar. *, P < 0.01 vs. wild-type response by ANOVA.