Table 2.

Variants with significant or suggestive associations to preeclampsia within genes coding for coagulation proteins. Loss of function (LoF) is given per gene. All variants in Table 2 had a The American College of Medical Genetics and Genomics classification of variant of uncertain significance due to not enough evidence.

RSID number	Gene name	P-value	OR (95% confidence interval)	MAFcases	MAFcontrols	Consequence (distance from exon, base pairs)	LoFtool*
rs1800385	VWF	3.57E-4	1.72 (1.27 – 2.32)	0.059	0.035	missense variant, V1565L	0.03
rs34444862	VWF	0.01	2.30 (1.19 – 4.35)	0.015	0.007	intron variant (−8)
rs34230288	VWF	0.02	2.18 (1.11 – 4.17)	0.014	0.007	missense variant, A2178S
rs36219245	ADAMTS13	8.62E-4	0.57 (0.40 – 0.80)	0.053	0.089	splice region variant (+4)	0.52
rs36218903	ADAMTS13	2.28E-3	3.06 (1.42 – 6.52)	0.012	0.004	intron variant (−33)
rs41314453	ADAMTS13	0.04	1.97 (0.99 – 3.78)	0.013	0.007	missense variant, A732V
rs5898	F2	0.03	1.31 (1.01 – 1.69)	0.077	0.060	synonymous variant, P395P	0.13
rs2301515	F5	8.06E-3	1.21 (1.05 – 1.39)	0.014	0.007	intron variant (−50)	0.09
rs6023	F5	0.01	1.48 (1.07 – 2.03)	0.050	0.034	splice region variant (+7)
rs6025	F5	0.05	1.49 (1.01 – 2.21)	0.030	0.021	missense variant, R534Q
rs9332688	F5	0.02	2.10 (1.07 – 3.98)	0.014	0.007	intron variant (−32)
rs900258823	F5	0.05	1.49 (1.01 – 2.21)	0.030	0.021	intron variant (−7098)
rs6042	F7	0.02	1.32 (1.04 – 1.67)	0.086	0.067	synonymous variant, H176H	0.07
rs6109	SERPINA5	5.70E-3	1.22 (1.06 – 1.41)	0.313	0.272	intron variant (−34)	0.06
rs6115	SERPINA5	0.04	1.15 (1.01 – 1.32)	0.367	0.335	missense variant, S64N
rs5878	SERPINC1	0.02	1.17 (1.02 – 1.35)	0.316	0.282	synonymous variant, Q337Q	na
rs5877	SERPINC1	0.03	1.17 (1.01–1.34)	0.301	0.269	synonymous variant, V327V	na

^*LoF tool – (loss of function tool); score of LoF susceptibility per gene < 0.2 = probably damaging, 0.2–0.7 = possibly damaging, > 0.7 = benign

na – not available

RSID – Single nucleotide polymorphism identifier, OR – Odds Ratio, MAF – Minor Allele Frequency