Skip to main content
[Preprint]. 2025 Jul 10:2025.07.06.663368. [Version 1] doi: 10.1101/2025.07.06.663368

Fig. 1: Characterization of H53 tumors in mice with HER2V777L and P53fl/fl or P53R172H.

Fig. 1:

(A) Key to the genotype of the murine breast cancer models. (B) Representative hematoxylin and eosin (H&E) staining of image of tumor slides from H, H53wt/fl, H53wt/172, H53fl/fl, H53fl/172 mice. Scale bars of low-power images are 5 mm. Scale bars of high-power images are 500 μm. (C) Immunohistochemistry (IHC) staining of HER2, ERα, SMA of mammary gland tumor tissue sections from H53wt/fl, H53fl/fl, and H53fl/172 mice, respectively. Scale bars of low-power images are 5 mm. Scale bars of high-power images are 100 μm. (D) Kaplan-Meier analysis shows overall survival (right) and tumor-free (left) of H, and H53 null mice, respectively. (E) Kaplan-Meier analysis shows overall survival (right) and tumor-free (left) of H, H53wt/fl, H53wt/172, and H53fl/172 mice, respectively.