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. Author manuscript; available in PMC: 2025 Jul 16.
Published in final edited form as: Mitochondrial Commun. 2025 Mar 26;3:26–43. doi: 10.1016/j.mitoco.2025.03.001

Fig. 5.

Fig. 5.

Transcriptomic analysis corroborated the findings of enhanced tumorigenic and metastatic potential. A) Gene set enrichment analysis results. B) Force directed layout display of PPI networks. Boxed cluster is functionally enriched to be migration/invasion related. C) Top 10 enriched histone modifications associated with upregulated DEGs post-MT-ND5 mutations in HEK293 cells. The Epigenomics Roadmap Histone Modification ChIP-seq gene set was used. Image modified from EnrichR. D) Top 10 enriched pathways for all differentially expressed proteins (DEPs) identified in basal subtype breast cancer against all other breast cancer subtypes. Image modified from Enrichr. E) A model for the activity of SIRT6 and the upregulation of genes regulated by H3K9ac. The upregulation of genes regulated by H3K9ac correlates with decreased activity of SIRT6.