Table 1.
Summary of clinical and pathological features of cases with eosinophilic globules in fumarate hydratase-deficient renal cell carcinoma.
| No. | Publication Date/Author | Gender/Age | HLRCC evidence and family history | Surgical approach | Tumor size(cm) | Pathological morphological features | Immunohistochemistry | Other findings | Follow-up | |
|---|---|---|---|---|---|---|---|---|---|---|
| FH | 2SC | |||||||||
| 1 | 2017/Steven C Smith | Male/11 | Germline G354R FH mutation | Radical nephrectomy | 8.5 | Solid, tubular, and cystic; Eosinophilic cytoplasm; Eosinophilic cytoplasmic inclusions | – | + | / | NED, >84 months |
| 2 | Male/40 | Homozygous p.K80 fs FH mutation in separate tumours | Radical nephrectomy | 0.2 and 0.4 | Solid, nodular; Eosinophilic cytoplasm; Eosinophilic cytoplasmic inclusions | – | + | / | Liver metastasis, of high grade, at presentation | |
| 3 | Male/41 | / | Partial nephrectomy | 5 | Solid; Eosinophilic cytoplasm; Eosinophilic cytoplasmic inclusions | – | + | Renal: Multilocular cystic change | NED, 48 months (oncocytic RCC); metastasis at 3 months after high-grade FHRCC nephrectomy | |
| 4 | 2020/Nicolas Wyvekens | Female/50 | Cutaneous leiomyomata; Uterine leiomyoma | Nephrectomy with lymphadenectomy | FHRCC:11 Uterine leiomyoma: none | FHRCC: Tubulocystic and papillary growth pattern, prominent nucleoli, perinucleolar halos; Uterine leiomyoma: Staghorn-like blood vessels, high cellularity, ovoid nuclei, prominent nucleoli, eosinophilic cytoplasmic globules |
FHRCC: -; Uterine leiomyoma: - | / | / | Local recurrence and subsequent treatment one year later; NED, 14 months |
| 5 | Female/46 | Cutaneous leiomyomata; Uterine leiomyoma | Partial nephrectomy | First recurrent tumor nodule:1.2 Second local recurrence:1.3-3(multiple retroperitoneal nodules) Lymph node metastases:4 Uterine leiomyoma: none |
FHRCC recurrence and metastasis: Papillary growth pattern, large tumor cells, prominent nucleoli with perinuclear halos, abundant cytoplasmic “colloid-like” inclusions; Uterine leiomyoma: Alveolar edema, staghorn-like blood vessels, intracytoplasmic globules |
FHRCC recurrence: -; Uterine leiomyoma: - |
/ | / | Local recurrence | |
| 6 | 2022/Athanase Billis | Female/45 | Uterine leiomyoma | / | 7.5 | Papillary arrangement, solid arrangement, tubulocystic arrangement, eosinophilic cytoplasm, large nucleoli surrounded by a clear halo, eosinophilic inclusions (round and oval) | – | + | / | NED, 15 months |
| 7 | Female/35 | Uterine leiomyoma | / | 21 | Papillary arrangement, solid arrangement, eosinophilic cytoplasm, large nucleoli surrounded by a clear halo, eosinophilic inclusions (round and oval) | – | + | / | NED, 32 months | |