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. 2025 Jun 11;301(7):110364. doi: 10.1016/j.jbc.2025.110364

Figure 4.

Figure 4

scRNA-Seq analysis of P21 control and Exosc10 cKO testes.A, UMAP plots of combined (left), control (middle), and Exosc10 cKO (right) testicular cells. Each dot represents a single cell, with clusters identified by distinct colors. Cell populations include spermatogonia (SPG), spermatocytes (Scytes), round spermatids (Stids), elongating Stids (Elongating), Sertoli cells, Leydig cells, stromal cells, myoid cells, endothelial cells, and macrophages. B, dot plot showing expression levels of selected marker genes in each cluster. C, bar graph illustrating the number of cells in each cluster from control and Exosc10 cKO testes. D, bar graph showing the percentage distribution of cell clusters in control and Exosc10 cKO testes. E, UMAP visualization of combined (left), control (middle), and Exosc10 cKO (right) germ cells, with each dot representing a single germ cell and distinct germ cell clusters represented by different colors. F, dot plot for the expression of selected marker genes in each germ cell cluster. G, bar graph showing the number of germ cells in each cluster from control and Exosc10 cKO testes. H, bar graph displaying the percentage distribution of germ cell clusters in control and Exosc10 cKO testes. cKO, conditional KO; scRNA-Seq, single-cell RNA-Seq; UMAP, Uniform Manifold Approximation and Projection.