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. 2025 Jun 11;301(7):110364. doi: 10.1016/j.jbc.2025.110364

Figure 7.

Figure 7

Combined analysis of transcript changes in Exosc10 cKO spermatocytes (Scytes) during meiotic prophase I.A, Venn diagram illustrating downregulated genes across leptotene, zygotene, pachytene, and diplotene Scytes between control and Exosc10 cKO samples. B, dot plot showing the Gene Ontology (GO) terms for overlapping downregulated genes in (A). C, same as (A) but for upregulated genes. D, dot plot showing the GO terms for overlapping upregulated genes in (C). E, dot plot displaying selected downregulated genes associated with spermatogenesis, rRNA processing, and ribosome assembly. F, RT–qPCR analysis of expression levels of genes linked to ribosome assembly, rRNA processing, and spermatogenesis in isolated spermatogenic cells from control and Exosc10 cKO mice. The expression level of genes in control relative to β-actin was set to 1. Data are presented as mean ± SD from three biologically independent replicates. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001. cKO, conditional KO; qPCR, quantitative PCR.