Table 1.
UV absorption ratios and CD intensities of 1 in various solvents correlated to solvent polarity parameter
| Solvent | E
|
A313/A295 | Δɛ322 | Solubility* |
|---|---|---|---|---|
| Cyclohexane | 0.006 | − | − | I |
| NEt3 | 0.043 | − | − | I |
| CCl4 | 0.052 | 0.779 | −191.8 | S |
| Di-n-Bu ether | 0.071 | − | − | I |
| Diethyl ether | 0.117 | − | − | I |
| t-Bu Me ether | 0.148 | − | − | I |
| 1,4-Dioxane | 0.164 | 0.811 | −189.0 | S |
| 1,1,1-TCE | 0.170 | 0.793 | −251.7 | S |
| THF | 0.207 | 0.860 | −121.9 | S |
| EtOAc | 0.228 | 0.719 | −203.8 | S |
| 1,2-DME | 0.231 | 0.782 | −257.9 | S |
| TEGDME | 0.253 | 0.752 | −247.6 | S |
| CHCl3 | 0.259 | 0.938 | −20.5 | S |
| MeOAc | 0.287 | 0.739 | −353.3 | S |
| CH2Cl2 | 0.309 | 0.958 | −57.7 | S |
| 1,2-DCE | 0.327 | 0.903 | −102.7 | S |
| Triacetin | 0.330 | 0.744 | −287.8 | S |
| NMP | 0.355 | 0.800 | −243.6 | S |
| t-BuOH | 0.389 | − | − | I |
| DMAC | 0.401 | 0.758 | −210.4 | S |
| DMF | 0.404 | 0.752 | −215.8 | S |
| DMSO | 0.444 | 0.679 | −321.0 | S |
| CH3CN | 0.460 | 0.672 | −398.8 | S |
| IPA | 0.546 | − | − | I |
| EtOH | 0.654 | − | − | I |
| MeOH | 0.762 | 0.611 | −932.0 | P |
| Ethylene glycol | 0.799 | − | − | I |
| 1,1,1-TFE | 0.898 | 0.679 | −325.1 | S |
| H2O | 1.000 | − | − | I |
| HFIP | 1.068 | 0.784 | −187.9 | S |
*
Solubility indicator: S, soluble; I, insoluble; P, partial solubility.
TCE, 1,1,1-trichloroethane; THF, tetrahydrofuran; DME, dimethyl ether 1,2-dimethoxyethane; TEGDME, triethylene glycol DME; 1,2 DCE, 1,2 dichloroethane; DMF, dimethylformamide; IPA, isopropanol; TFE, trifluoroethanol; HFIP, hexfluoroisopropanol.