Fig. 1.

Life expectancy and years of life lost based on social isolation and/or loneliness (A) Estimated life expectancy at age 45 years based on social isolation (B) Estimated life expectancy at age 45 years based on loneliness (C) Estimated life expectancy at age 45 years based on social isolation and loneliness The model was adjusted for sociodemographic (educational level, residential status, and employment status), lifestyle (smoking, alcohol intake, sleep duration, and body mass index), and health-related factors (self-rated health status, comorbidities, depression, and activities of daily living)