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. 2025 Mar 25;46(8):2093–2104. doi: 10.1038/s41401-025-01531-9

Fig. 2. Mechanisms of action of natural products targeting cholesterol biosynthesis in cancer.

Fig. 2

Cancer cells normally upregulate cholesterol biosynthesis by activating SREBP2 signaling to gain a sufficient base for proliferation. Therefore, inhibition of cholesterol synthesis may be a promising pathway to inhibit cancer progression. SREBP Sterol-regulatory element binding protein, SCAP SREBP cleavage-activating protein, INSIG insulin-induced gene protein, COPII coat protein complex II, S1P site-1 protease, S2P site-2 protease, HMGCS HMG-CoA synthetase, HMGCR HMG-CoA reductase, SQS Squalene Synthase, SQLE squalene epoxidase.